Development of New Enantioselective Reactions Using N-Heterocyclic Carbenes, PhD

Faculty of Science, Czech Republic (the)

Visit course webpage

Photos and Videos

Study options for this course

The award	How you will study	Study duration	Course start	Domestic course fees	International course fees
PhD	Full-time	find out	find out	find out	find out

About Development of New Enantioselective Reactions Using N-Heterocyclic Carbenes, PhD - at Faculty of Science

Project summary:

Asymmetric organocatalysis has grown into one of the pillars of asymmetric catalysis, employing various small organic molecules as efficient catalysts, including N-heterocyclic carbenes (NHC). NHCs can efficiently catalyze transesterifications, acylations, polymerizations, and other reactions, and they also found widespread application as ligands in transition metal catalysis. Whereas NHCs containing imidazolylidene framework dominate as ligands in transition metal catalysis (to stabilize coordinatively unsaturated active species), triazolylidene carbenes are the main players in catalytic processes using NHC as catalysts. The vast majority of enantioselective transformations catalyzed by NHCs proceed through the umpolung of aldehydes. In the last few years, azolium dienolate as an interesting intermediate generated from carbonyl compounds and NHC, has received attention as an alternate strategy for remote functionalization (?-position of enals). We have recently developed new type of enantioselective formal cycloadition reaction based on azolium dienolate chemistry. The goal of the project is to develop new enantioselective carbon-carbon bond-forming reactions and the construction of biologically relevant (hetero)cyclic molecules based on azolium dienolates. Requirements: M.Sc. degree in organic chemistry, organometallic chemistry or related fields, experience with synthesis and characterization of small molecules, strong interest in organic synthesis and catalysis, open to learning new techniques and working in a team, good knowledge of English.

Selected recent publications of the research group:

1. L

Learn more about Development of New Enantioselective Reactions Using N-Heterocyclic Carbenes, PhD - at Faculty of Science

Visit course webpage

Entry requirements

Contact Faculty of Science to find course entry requirements.

Fees, Funding and Scholarships at Faculty of Science

This text facilitates quick navigation of the various types of scholarships but does not provide a full list of rules and policies regulating this field. The granting and payments of scholarships is governed primarily by the Scholarships and Bursaries Rules of Charles University (cuni.cz/UKEN-727.html), the Rules for Granting Scholarships at FSc, and the relevant measures issued by the Dean (natur.cuni.cz/fakulta/studium/bc-nmgr/predpisy-a-poplatky/stipendia; Czech only).

Students may obtain the following scholarships:

accommodation bursary;
bursary for a student in difficult social circumstances;
scholarship for outstanding academic achievement (“mark-based”);
bursary in a case worthy of special consideration;
bursary to support study abroad;
bursary for a CU student in an acutely difficult situation;
bursary to support study in the Czech Republic;
bursary for excellent research, development, innovation, artistic, or other creative achievements contributing to enhanced knowledge;
scholarship for RDI (research, development, and innovation) under special legislation;
motivation bursary for 1st year bachelor’s programme students;
motivation bursary for 1st year post-bachelor’s programme students;
sports bursary;
doctoral bursary.

Certain scholarships are granted to students automatically (without student applications), whereas others are granted further to an application (electronic or paper, depending on the type of scholarship). Bursaries are neither taxed nor included in stated income. You can find answers to frequently asked questions regarding scholarships on the Faculty website (natur.cuni.cz/fakulta/studium/helpdesk/faq-stipendia; Czech only).

For more information check our dedicated website.